The effect of Vitamin D supplementation on nerve conduction studies in type 2 diabetes mellitus Indonesian patients

Aida Fitri¹, Hasan Sjahrir¹, Adang Bachtiar², M. Ichwan³

¹Department of Neurology Faculty of Medicine Universitas Sumatera Utara, Indonesia
²Faculty of Public Health Universitas Indonesia
³Department of Pharmacology and Therapeutic Faculty of Medicine Universitas     Sumatera Utara, Indonesia

Background: Diabetic neuropathy (DN) is one of the most common complication in patients with type 2 diabetes mellitus

(T2DM). Diabetic neuropathy is the most common form of neuropathy in developed countries. Low levels of circulating

vitamin D may contribute to large fiber neuropathy in diabetic patients. In some literatures, there are conflicting reports on

the effect of vitamin D on nerve conduction studies (NCSs).

Objective: To investigate the effect of vitamin D supplementation on NCSs in T2DM Indonesian patients.

Methods: Fifty subjects with T2DM in Haji Adam Malik General Hospital Medan, were randomly divided into 2 groups.

The groups were treated for 10 weeks either with placebo or vitamin D (D3) supplementation of 50.000 IU/week, double-

blind trial. They were evaluated by routine NCSs in upper and lower limbs, before and 10 weeks after placebo or vitamin

D supplementation. The effect of vitamin D supplementation on NCSs was analyzed using linear regression.

Results: Vitamin D supplementation had significant decrease in distal latencies (DLs) of motor median, peroneal, and tibial

nerve, motor and sensory ulnar nerve (p <0.001), increase in amplitudes (As) of motor and sensory median and ulnar nerve,

motor peroneal and tibial nerve, and sensory sural nerve (p <0.001), and increase in nerve conduction velocities (NCVs)

of motor median and peroneal nerve, motor and sensory ulnar nerve (p <0.001). There were neither significant effect of

vitamin D supplementation in DL and NCVs of sensory median and sural nerve, nor NCVs of motor tibial nerve.

Conclusion: Vitamin D supplementation for 10 weeks had effect on NCSs in T2DM Indonesian patients.

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