Retnaningsih, Marcus Adityawan Bahroen, Riris Lestari, Dodik Tugasworo, Dwi Pudjonarko
Departement of Neurology, School of Medicine, University of Diponegoro / dr. Kariadi Hospital Semarang, Indonesia
Background. Atherosclerosis in post-ischemic stroke patients is marked by a thickness of the carotid intima-media. Resistin contributes to dysfunction of the endothelial walls. Association of serum resistin in the progression of atherosclerosis in post-ischemic stroke patients has been studied rarely.
Objectives. Purpose of this study was to know the association of serum resistin and progression of carotid intima-media thickness (CIMT) in post-ischemic stroke patients.
Methods. This study was a cohort observational study in outpatient neurology clinic in dr. Kariadi hospital Semarang, within the period of October 2014 to April 2015. The level of serum resistin was determined and carotid duplex ultrasound was performed on subject. After 6 months, the second carotid duplex ultrasound examination was performed. Data was analyzed by binary logistic regression to assess the association between serum resistin and progression of CIMT.
Results. 72 subjects, mean age 61.64 (SD = 7.99) years, 44 males (61.1%), were recruited in this study. In 49 cases (68.05%) progression of CIMT was found. Mean serum resistin level was 12.4 (SD = 10.2) ng/mL. No significant difference was found in serum resistin levels between patients with and without progression of CIMT
Conclusion. There was no association between serum resistin levels and progression of intima-media thickness of the internal carotid arteries in post-ischemic stroke patients.